What happens to ammonia formed from deamination in the liver?

The process of deamination in the liver involves the removal of an amino group from amino acids, which results in the formation of ammonia. Ammonia is a toxic substance, so the body must efficiently process it to prevent harmful effects. In the liver, ammonia undergoes a conversion process called the urea cycle, where it is transformed into urea.

Urea is far less toxic than ammonia and becomes soluble in water, allowing it to be transported safely in the bloodstream to the kidneys, where it is ultimately excreted in urine. This conversion not only detoxifies ammonia but also allows for the safe elimination of nitrogen waste from the body.

In summary, the transformation of ammonia to urea is crucial for maintaining nitrogen balance and preventing toxicity, making this a pivotal metabolic function of the liver.